Myelofibrosis Self Assessment

The primary molecular mechanism driving myelofibrosis involves constitutive activation of which signaling pathway?

PI3K-AKT pathway

MAPK/ERK pathway

JAK-STAT pathway

Wnt/β-catenin pathway

Which of the following genes listed is a primary driver mutation in myelofibrosis?

JAK1

IDH2

MPL

ASXL1

Which of the following statements correctly describes clinical features of myelofibrosis?

Pruritus is driven by pro-inflammatory cytokines and reflects disease progression

Splenomegaly results from extramedullary hematopoiesis and may cause abdominal symptoms

Bone pain is uncommon and typically suggests leukemic transformation

Fatigue occurs primarily in anemic patients and improves with transfusions

Which of the following interventions is an appropriate strategy for improving symptoms for patients with MF?

Prescribe methylphenidate and increased physical activity to improve fatigue

Prescribe systemic corticosteroids and recommend over-the-counter antihistamines for management of pruritus

Prescribe oral levofloxacin and crowd avoidance to decrease risk of infection

Prescribe JAK inhibitors to decrease inflammatory cytokines and improve overall symptoms

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