Test your knowledge on high-grade B-cell lymphoma

Which of the following is consistent with double-hit lymphoma?
Non-germinal center B-cell (non-GCB) with immunohistochemistry (IHC) expressions of MYC and BCL2
GCB with fluorescence in situ hybridization (FISH) rearrangements of MYC and BCL2
GCB with IHC without expressions of MYC and BCL2
Non-GCB with FISH without rearrangements MYC and BCL2
Which of the following statements about double-hit/triple-hit lymphoma (DHL/THL) is NOT true?
Intensive chemotherapy regimens are associated with higher rates of complete response (CR) and progression-free survival but not overall survival for DHL/THL.
Studies have shown the benefit of consolidative autologous stem cell transplantation following intensive frontline treatment in DHL/THL
Patients receiving intensive chemotherapy regimens for DHL/THL should receive intrathecal chemotherapy
Patients with DHL/THL are less likely to achieve a CR following salvage therapy
What are the gene rearrangements that are seen with double-hit/triple-hit lymphoma?
MYC, BCL2, BCL6
FLT3, IDH1, NPM1
CEBPA, RUNX1, ASXL3
MLL, BCL2, FLT3
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