Test your knowledge of biomarker testing for genetic evaluation of GISTs

What is the primary mechanism of action of imatinib in the treatment of GIST?
Blocking the growth factor receptor HER2
Inhibiting the tyrosine kinase activity of the KIT and PDGFRA proteins
Targeting the DNA repair pathway
Targeting the PDGFRA D842V mutation
A patient with GIST develops resistance to imatinib. Which of the following mutations is most likely to be associated with this resistance?
KIT exon 9 mutation
KIT exon 11 mutation
KIT exon 13 mutation
KIT exon 22 mutation
Which of the following is a potential side effect of sunitinib?
Hand-foot syndrome
Hypertension
Impaired wound healing
All of the above
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