Clinical Case Series - Lymphoma 2 - Question 3

What is your recommendation if a patient develops grade 1 diarrhea with ibrutinib?
Initiate infectious gastroenteritis workup; if negative, continue ibrutinib, and manage diarrhea with supportive care
Initiate infectious gastroenteritis workup; if negative, hold ibrutinib until resolution of diarrhea, and manage diarrhea with supportive care
Initiate infectious gastroenteritis workup; if negative, dose-reduce ibrutinib and manage diarrhea with supportive care
Initiate infectious gastroenteritis workup; if negative, switch to an alternative therapy
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