Test your knowledge of first-line treatment for metastatic HR+ HER2- breast cancer

Which is routinely recommended as first-line treatment for HR+ HER2- metastatic breast cancer?
Chemotherapy
Aromatase inhibitor plus CDK4/6 inhibitors
Combination chemotherapy and endocrine therapy
Immunotherapy
What are two main adverse effects from the combination of aromatase inhibitors plus ribociclib?
Diarrhea and headaches 
Rash and diarrhea
Neutropenia and hepatobiliary toxic effects
Rash and anorexia
What is one contraindication for using ribociclib? 
Uncontrolled or significant cardiac disease 
Eczema
Prior exposure to tuberculosis
Selective serotonin reuptake inhibitor (SSRI) use
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