Test your knowledge on upper GI involvement in GvHD

Upper GI involvement affects approximately what percentage of hematopoietic stem cell transplant recipient patients with acute GvHD?

10%

30%

50%

70%

How does ibrutinib act to reduce GvHD symptoms?

By inhibiting ROCK2, which helps to decrease the proinflammatory cytokines IL-21 and IL-17, and decreases antibody presence and fibrosis

By inhibiting JAK1 and JAK2, which mediate the downstream effects of multiple cytokines, resulting in increased Treg numbers and lower levels of collagen deposition

By inhibiting Bruton’s tyrosine kinase (BTK), a mechanism that helps block the activation of B cells, and also blocks IL-2 inducible kinase (ITK), which helps avoid the T cell activation and cytokine release from the T-cell pathway

What are the topical options often used for gastrointestinal involvement of GvHD?

Triamcinolone

Dexamethasone

Beclomethasone

Budesonide

Both C and D (Beclomethasone is a compounded medication used often for upper involvement of GvHD. Budesonide is in a pill form and can be given as often as 3 times daily)